Raines, Wagner and Salinas examine a case study involving intraamniotic infection (IAI) and nurses’ role in caring for a newborn exposed to IAI. When an infection occurs, the fetal inflammatory response is activated and is manifested by umbilical cord inflammation, which may result in the clinical signs and symptoms of sepsis. Newborns have an immature immune system; their immune system’s response to the inflammation impacts the newborn’s organ systems and culminates in early onset sepsis.